A19 between Thornaby and Crathorne reopens after lorry crash
No injuries have been reported.
Cleveland Police were among the emergency services at the scene.
Tom Loach, from National Highways, said there had been "substantial" damage to both vehicles.
He said a team of 32 people took part in the clean-up operation.
"One of the HGVs was carrying shopping goods, milk and eggs, cooking oil," Mr Loach said.